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A Meta-Analysis of Microglial Heterogeneity and Gene Coexpression Networks in Aging and Neurodegeneration

2025-12-01

Abstract excerpt

Microglia are a key brain cell population pivotal for homeostasis, and in brain aging and neurodegeneration they exhibit both adaptive phagocytic and maladaptive proinflammatory responses. To understand this dynamics, I independently analyzed five human datasets, totaling 83,190 microglial nuclei and covering Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal lobar degeneration...

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Literature Corpus work
8589bbda-79ab-5e0e-af1b-e97b32824648
DOI
10.20944/preprints202512.0004.v1
Open publication

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