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Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbations

2021-06-07

Abstract excerpt

<title>Abstract</title> <p>Microglia have fundamental roles in health and disease, however effects of age, sex and genetic factors on human microglia have not been fully explored. We applied bulk and single cell approaches to comprehensively characterize human microglia transcriptomes and their associations with age, sex and <italic>APOE</italic>. We identified a novel microglial signature, characterized its expr...

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Literature Corpus work
81697cc9-e146-5c4a-8214-7056236ec518
DOI
10.21203/rs.3.rs-523348/v1
Open publication

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