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Article

Evolutionary conservation of possible functional domains of the human and murine XIST genes.

Human molecular genetics - 1 Jun 1993

Hendrich B D, Brown C J, Willard H F

Abstract excerpt

The human XIST gene, a candidate for a role in X chromosome inactivation, has recently been cloned and sequenced, yielding a 17 kb cDNA with no apparent significant, conserved open reading frame. In addition, the XIST transcript has been localized within the nucleus to the Barr body by RNA in sit...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
DNA
Dosage Compensation, Genetic
Gene Expression Regulation
Genes
Humans
Mammals
Methylation
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Open Reading Frames

Phylogeny

Primates

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 8353487
DOI: 10.1093/hmg/2.6.663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8353487-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Evolutionary conservation of possible functional domains of the human and murine XIST genes.PMID 8353487Read ↗

A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene TsxSemantic proximity Read ↗

Variability of sequence surrounding the Xist gene in rodents suggests taxon-specific regulation of X chromosome inactivation.Semantic proximity Read ↗

Chromosomal silencing and localization are mediated by different domains of Xist RNA.Semantic proximity Read ↗

Unleashing XIST from X-chromosome inactivationSemantic proximity Read ↗

Expression and Function of a Large Non‐coding RNA Gene XIST in Human CancerSemantic proximity Read ↗

Extensive remodelling of <i>XIST</i> regulatory networks during primate evolutionSemantic proximity Read ↗

Advances in understanding chromosome silencing by the long non-coding RNA Xist.Semantic proximity Read ↗

Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.Semantic proximity Read ↗

Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expressionSemantic proximity Read ↗

Requirement for Xist in X chromosome inactivation.Semantic proximity Read ↗

Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formationSemantic proximity Read ↗

Cross-species examination of X-chromosome inactivation highlights domains of escape from silencingSemantic proximity Read ↗

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