Article
Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.
Human molecular genetics - 15 Feb 2011
Chureau Corinne, Chantalat Sophie, Romito Antonio, Galvani Angélique, Duret Laurent, Avner Philip, Rougeulle Claire
Abstract excerpt
X chromosome inactivation (XCI) is an essential epigenetic process which involves several non-coding RNAs (ncRNAs), including Xist, the master regulator of X-inactivation initiation. Xist is flanked in its 5' region by a large heterochromatic hotspot, which contains several transcription units including a gene of unknown function, Ftx (five prime to Xist). In this article, we describe the characterization and...
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