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Human <i>APOE</i> allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse <i>Apoe</i> in transgenic mouse models of Alzheimer amyloidosis

2024-05-01

Abstract excerpt

<h4>Background</h4> Apolipoprotein E (apoE) modulates the deposition of amyloid β (Aβ) aggregates in Alzheimer’s disease (AD) in an isoform-dependent manner. In transgenic mouse models of AD-amyloidosis, replacing mouse Apoe alleles with human APOE variants suppresses fibrillar Aβ deposits. In the PD-APP transgenic mouse model, deletion of the Apoe gene led to selective reduction of fibrillar deposits with inc...

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Literature Corpus work
fba29fea-75dc-5a7e-8da4-31ea3941f9dd
DOI
10.1101/2024.04.30.591932
Open publication

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Human <i>APOE</i> allelic variants suppress the formation of diffuse and fibrillar Aβ deposits relative to mouse <i>Apoe</i> in transgenic mouse models of Alzheimer amyloidosisDOI 10.1101/2024.04.30.591932
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