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Article

Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.

Communications biology - 20 May 2024

Gurdon Brianna, Yates Sharon C, Csucs Gergely, Groeneboom Nicolaas E, Hadad Niran, Telpoukhovskaia Maria, Ouellette Andrew, Ouellette Tionna, O'Connell Kristen M S, Singh Surjeet, Murdy Thomas J, Merchant Erin, Bjerke Ingvild, Kleven Heidi, Schlegel Ulrike, Leergaard Trygve B, Puchades Maja A, Bjaalie Jan G, Kaczorowski Catherine C

Abstract excerpt

Alzheimer's disease (AD) is broadly characterized by neurodegeneration, pathology accumulation, and cognitive decline. There is considerable variation in the progression of clinical symptoms and pathology in humans, highlighting the importance of genetic diversity in the study of AD. To address this, we analyze cell composition and amyloid-beta deposition of 6- and 14-month-old AD-BXD mouse brains. We utilize the...

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Identifiers

PMID: 38769398
DOI: 10.1038/s42003-024-06242-1
PMCID: PMC11106287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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