Article

Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer’s Disease Independent of Amyloid and Tau Pathology

2023-12-20

Abstract excerpt

<h4>Structured Abstract</h4> <h4>INTRODUCTION</h4> MODEL-AD is creating and distributing novel mouse models with humanized, clinically relevant genetic risk factors to more accurately mimic LOAD than commonly used transgenic models. <h4>METHODS</h4> We created the LOAD2 model by combining APOE4, Trem2*R47H, and humanized amyloid-beta. Mice aged up to 24 months were subjected to either a control diet or a high-f...

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Literature Corpus work: 5bd0bc25-60a7-5376-8a3e-59da01ac1c11
DOI: 10.1101/2023.12.19.571985

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