Article
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer's disease.
Scientific data - 15 Oct 2021
Forner Stefania, Kawauchi Shimako, Balderrama-Gutierrez Gabriela, Kramár Enikö A, Matheos Dina P, Phan Jimmy, Javonillo Dominic I, Tran Kristine M, Hingco Edna, da Cunha Celia, Rezaie Narges, Alcantara Joshua A, Baglietto-Vargas David, Jansen Camden, Neumann Jonathan, Wood Marcelo A, MacGregor Grant R, Mortazavi Ali, Tenner Andrea J, LaFerla Frank M, Green Kim N
Abstract excerpt
Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms and testing interventions and therapeutics. For disorders such as Alzheimer's disease in which numerous models are being generated, a challenging first step is to identify the most appropriate model and age to effectively evaluate new therapeutic approaches. Here we conducted a detailed phenotypic characterization of the 5xFAD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.