Article

A humanized Aβ mouse model reveals E4-dependent cognitive impairments, microglial activation, and cerebrovascular dysfunction

2026-07-28

Abstract excerpt

Apolipoprotein E4 (E4) increases the risk of Alzheimer's disease (AD) by up to 12-fold. However, understanding of the mechanisms underlying this increased risk has been limited by a lack of preclinical models that accurately reflect the effects of E4 in the presence of humanized non-mutant amyloid-β precursor protein (hAβPP). Therefore, we studied novel humanized APOE and hAβPP mice to investigate the contribution...

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Literature Corpus work: dd8519df-62cf-53e7-ae44-4b67efe44b1a
DOI: 10.64898/2026.07.28.740806

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