Article

Genetic variation in <i>ALDH4A1</i> predicts muscle health over the lifespan and across species

2021-09-10

Abstract excerpt

Environmental stress can negatively impact organismal aging, however, the long-term impact of endogenously derived reactive oxygen species from normal cellular metabolism remains less clear. Here we define the evolutionarily conserved mitochondrial enzyme ALH-6/ALDH4A1 as a biomarker for age-related changes in muscle health by combining C. elegans genetics and a gene-wide association study (GeneWAS) from aged hum...

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Literature Corpus work: 30b0da31-082a-5ef7-9ba3-a245fbad0857
DOI: 10.1101/2021.09.08.459547

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