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Article

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.

Nature - 24 Oct 2002

Herndon Laura A, Schmeissner Peter J, Dudaronek Justyna M, Brown Paula A, Listner Kristin M, Sakano Yuko, Paupard Marie C, Hall David H, Driscoll Monica

Abstract excerpt

The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity...

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PMID: 12397350
DOI: 10.1038/nature01135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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