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Article

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.

Journal of inherited metabolic disease - 1 May 2002

Johnson T E, Henderson S, Murakami S, de Castro E, de Castro S H, Cypser J, Rikke B, Tedesco P, Link C

Abstract excerpt

More than 40 single-gene mutants in Caenorhabditis elegans have been demonstrated to lead to increased lifespan (a rigorous, operational test for being a gerontogene) of 20% or more; these are referred to collectively as 'Age' mutants. Age mutants must change key functions that are rate-limiting determinants of longevity; moreover, important genes can be identified independently of prior hypotheses as to actual...

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Identifiers

PMID: 12137228
DOI: 10.1023/a:1015677828407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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