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Article

Comparison of proteomic and metabolomic profiles of mutants of the mitochondrial respiratory chain in Caenorhabditis elegans.

Mitochondrion - 1 Jan 2015

Morgan P G, Higdon R, Kolker N, Bauman A T, Ilkayeva O, Newgard C B, Kolker E, Steele L M, Sedensky M M

Abstract excerpt

Single-gene mutations that disrupt mitochondrial respiratory chain function in Caenorhabditis elegans change patterns of protein expression and metabolites. Our goal was to develop useful molecular fingerprints employing adaptable techniques to recognize mitochondrial defects in the electron transport chain. We analyzed mutations affecting complex I, complex II, or ubiquinone synthesis and discovered overarching...

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Identifiers

PMID: 25530493
DOI: 10.1016/j.mito.2014.12.004
PMCID: PMC4305019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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