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Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans.

Biochimica et biophysica acta. Molecular basis of disease - 1 Sept 2018

Gao Arwen W, Uit de Bos Jelmi, Sterken Mark G, Kammenga Jan E, Smith Reuben L, Houtkooper Riekelt H

Abstract excerpt

The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematode Caenorhabditis elegans has been widely used and has provided valuable knowledge in determining the regulatory mechanisms driving the aging process. Many genes...

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PMID: 28919364
DOI: 10.1016/j.bbadis.2017.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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