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Article

Genetic variation in ALDH4A1 is associated with muscle health over the lifespan and across species.

eLife - 26 Apr 2022

Villa Osvaldo, Stuhr Nicole L, Yen Chia-An, Crimmins Eileen M, Arpawong Thalida Em, Curran Sean P

Abstract excerpt

The influence of genetic variation on the aging process, including the incidence and severity of age-related diseases, is complex. Here, we define the evolutionarily conserved mitochondrial enzyme ALH-6/ALDH4A1 as a predictive biomarker for age-related changes in muscle health by combining Caenorhabditis elegans genetics and a gene-wide association scanning (GeneWAS) from older human participants of the US Health...

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Identifiers

PMID: 35470798
DOI: 10.7554/eLife.74308
PMCID: PMC9106327

Genes

ALDH4A1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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