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Article

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.

Genes & development - 1 Oct 2008

Neumann-Haefelin Elke, Qi Wenjing, Finkbeiner Elisabeth, Walz Gerd, Baumeister Ralf, Hertweck Maren

Abstract excerpt

Correlative evidence links stress, accumulation of oxidative cellular damage, and aging in several species. Genetic studies in species ranging from yeast to mammals revealed several pathways regulating stress response and life span, including caloric intake, mitochondrial respiration, insulin/IGF-1 (IIS), and JNK (c-Jun N-terminal kinase) signaling. How IIS and JNK signaling cross-talk to defend against diverse...

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Identifiers

PMID: 18832074
DOI: 10.1101/gad.478408
PMCID: PMC2559911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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