Article

Genetic mapping of lifespan and mitochondrial stress response in <i>C. elegans</i>

2025-06-26

Abstract excerpt

The mitochondrial unfolded protein response (UPR mt ) is one of the mito-nuclear regulatory circuits that restores mitochondrial function upon stress conditions, promoting metabolic health and longevity. However, the complex gene interactions that govern this pathway and its role in aging and healthspan remain to be fully elucidated. Here, we activated the UPR mt using doxycycline (Dox) in a genetically diverse...

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Literature Corpus work: 5e311ef7-687c-53c5-b446-d43db49b13b8
DOI: 10.1101/2025.06.26.661693

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