Article

Inhibition of <i>CERS1</i> in skeletal muscle exacerbates age-related muscle dysfunction

2023-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis of age-related skeletal muscle impairment. In humans, CERS1 abundance declines with aging in skeletal muscle cells and, correlates with biol...

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Literature Corpus work: d5b2f6a2-b03d-5108-a3a6-93f391ef88bc
DOI: 10.1101/2023.08.05.552113

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