Article

Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures

2016-10-21

Abstract excerpt

Genome-wide association studies (GWAS) suggest that the genetic architecture of complex diseases consists of unexpectedly numerous variants with small effect sizes. However, the polygenic architectures of many diseases have not been well characterized due to lack of simple and fast methods for unbiased estimation of the underlying proportion of disease-associated variants and their effect-size distribution. Applyi...

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Literature Corpus work: 2d6ae503-6837-5b5d-b4a0-682889d15809
DOI: 10.1101/080945

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