Article
Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.
The British journal of psychiatry : the journal of mental science - 1 Sept 2018
Calafato Maria Stella, Thygesen Johan H, Ranlund Siri, Zartaloudi Eirini, Cahn Wiepke, Crespo-Facorro Benedicto, Díez-Revuelta Álvaro, Di Forti Marta, Hall Mei-Hua, Iyegbe Conrad, Jablensky Assen, Kahn Rene, Kalaydjieva Luba, Kravariti Eugenia, Lin Kuang, McDonald Colm, McIntosh Andrew M, McQuillin Andrew, Picchioni Marco, Rujescu Dan, Shaikh Madiha, Toulopoulou Timothea, Os Jim Van, Vassos Evangelos, Walshe Muriel, Powell John, Lewis Cathryn M, Murray Robin M, Bramon Elvira
Abstract excerpt
BACKGROUND: There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined...
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