Article
The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology.
Nature reviews. Neurology - 1 Jul 2020
Smeland Olav B, Frei Oleksandr, Dale Anders M, Andreassen Ole A
Abstract excerpt
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality. Although the past two decades have seen limited improvement in the treatment of schizophrenia, research into the genetic causes of this condition has made important advances that offer new insights into the aetiology of schizophrenia. This Review summarizes the evidence for a polygenic architecture of schizophrenia that...
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