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Article

Construction and Application of Polygenic Risk Scores in Autoimmune Diseases.

Frontiers in immunology - 1 Jan 2022

Khunsriraksakul Chachrit, Markus Havell, Olsen Nancy J, Carrel Laura, Jiang Bibo, Liu Dajiang J

Abstract excerpt

Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with autoimmune diseases and provided unique mechanistic insights and informed novel treatments. These individual genetic variants on their own typically confer a small effect of disease risk with limited predictive power; however, when aggregated (e.g., via polygenic risk score method), they could provide meaningful...

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Identifiers

PMID: 35833142
DOI: 10.3389/fimmu.2022.889296
PMCID: PMC9271862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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