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Article

Progress in understanding the biological basis of polygenic disorders.

Current opinion in genetics & development - 1 Apr 2026

Wray N R, Lin T, Li A, de Almeida V, Ziller M, Zeng J

Abstract excerpt

Genome-wide association studies have provided empirical evidence that common diseases have a polygenic architecture, but with differences in estimable genetic architecture parameters such as proportion of the genomic sites associated with trait variation (polygenicity), the proportion of variance explained by those common DNA variants (SNP-based heritability), and signatures of selection evident from the...

Topics

Humans
Multifactorial Inheritance
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Mental Disorders
Gene Frequency

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41548389
DOI: 10.1016/j.gde.2025.102433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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