Article

Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis

2015-03-14

Abstract excerpt

Heritability analyses of GWAS cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here, we analyze the genetic architecture of schizophrenia in 49,806 samples from the PGC, and nine complex diseases in 54,734 samples from the GERA cohort. For schizophrenia, we infer an overwhelmingly polygenic disease architecture in which...

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Literature Corpus work: 68cfef68-e1bb-591f-acd5-c9793e23a11e
DOI: 10.1101/016527

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