Simultaneous discovery, estimation and prediction analysis of complex traits using a bayesian mixture model.

Abstract excerpt

Gene discovery, estimation of heritability captured by SNP arrays, inference on genetic architecture and prediction analyses of complex traits are usually performed using different statistical models and methods, leading to inefficiency and loss of power. Here we use a Bayesian mixture model that simultaneously allows variant discovery, estimation of genetic variance explained by all variants and prediction of...

Topics

• Animals
• Bayes Theorem
• Genetic Diseases, Inborn
• Humans
• Models, Genetic
• Polymorphism, Single Nucleotide
• Quantitative Trait, Heritable