Article
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis.
Nature genetics - 25 Mar 2012
Stahl Eli A, Wegmann Daniel, Trynka Gosia, Gutierrez-Achury Javier, Do Ron, Voight Benjamin F, Kraft Peter, Chen Robert, Kallberg Henrik J, Kurreeman Fina A S, Kathiresan Sekar, Wijmenga Cisca, Gregersen Peter K, Alfredsson Lars, Siminovitch Katherine A, Worthington Jane, de Bakker Paul I W, Raychaudhuri Soumya, Plenge Robert M
Abstract excerpt
The genetic architectures of common, complex diseases are largely uncharacterized. We modeled the genetic architecture underlying genome-wide association study (GWAS) data for rheumatoid arthritis and developed a new method using polygenic risk-score analyses to infer the total liability-scale variance explained by associated GWAS SNPs. Using this method, we estimated that, together, thousands of SNPs from...
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