Article
Polygenic risk scores across the extended psychosis spectrum.
Translational psychiatry - 26 Nov 2021
Smigielski Lukasz, Papiol Sergi, Theodoridou Anastasia, Heekeren Karsten, Gerstenberg Miriam, Wotruba Diana, Buechler Roman, Hoffmann Per, Herms Stefan, Adorjan Kristina, Anderson-Schmidt Heike, Budde Monika, Comes Ashley L, Gade Katrin, Heilbronner Maria, Heilbronner Urs, Kalman Janos L, Klöhn-Saghatolislam Farahnaz, Reich-Erkelenz Daniela, Schaupp Sabrina K, Schulte Eva C, Senner Fanny, Anghelescu Ion-George, Arolt Volker, Baune Bernhard T, Dannlowski Udo, Dietrich Detlef E, Fallgatter Andreas J, Figge Christian, Jäger Markus, Juckel Georg, Konrad Carsten, Nieratschker Vanessa, Reimer Jens, Reininghaus Eva, Schmauß Max, Spitzer Carsten, von Hagen Martin, Wiltfang Jens, Zimmermann Jörg, Gryaznova Anna, Flatau-Nagel Laura, Reitt Markus, Meyers Milena, Emons Barbara, Haußleiter Ida Sybille, Lang Fabian U, Becker Thomas, Wigand Moritz E, Witt Stephanie H, Degenhardt Franziska, Forstner Andreas J, Rietschel Marcella, Nöthen Markus M, Andlauer Till F M, Rössler Wulf, Walitza Susanne, Falkai Peter, Schulze Thomas G, Grünblatt Edna
Abstract excerpt
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the additive effects of multiple common genetic variants hold the potential to predict complex diseases and index severity...
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