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Article

Research review: Polygenic methods and their application to psychiatric traits.

Journal of child psychology and psychiatry, and allied disciplines - 1 Oct 2014

Wray Naomi R, Lee Sang Hong, Mehta Divya, Vinkhuyzen Anna A E, Dudbridge Frank, Middeldorp Christel M

Abstract excerpt

BACKGROUND: Despite evidence from twin and family studies for an important contribution of genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly associated specific DNA variants has proved challenging. In the pregenomics era the genetic architecture (number, frequency and effect size of risk variants) of complex genetic disorders was unknown. Empirical evidence for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25132410
DOI: 10.1111/jcpp.12295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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