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Article

Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis.

Nature genetics - 1 Dec 2015

Loh Po-Ru, Bhatia Gaurav, Gusev Alexander, Finucane Hilary K, Bulik-Sullivan Brendan K, Pollack Samuela J, de Candia Teresa R, Lee Sang Hong, Wray Naomi R, Kendler Kenneth S, O'Donovan Michael C, Neale Benjamin M, Patterson Nick, Price Alkes L

Abstract excerpt

Heritability analyses of genome-wide association study (GWAS) cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here we analyze the genetic architectures of schizophrenia in 49,806 samples from the PGC and nine complex diseases in 54,734 samples from the GERA cohort. For schizophrenia, we infer an overwhelmingly...

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Identifiers

PMID: 26523775
DOI: 10.1038/ng.3431
PMCID: PMC4666835

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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