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Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits.

Nature genetics - 1 Sept 2018

Zhang Yan, Qi Guanghao, Park Ju-Hyun, Chatterjee Nilanjan

Abstract excerpt

We developed a likelihood-based approach for analyzing summary-level statistics and external linkage disequilibrium information to estimate effect-size distributions of common variants, characterized by the proportion of underlying susceptibility SNPs and a flexible normal-mixture model for their effects. Analysis of results available across 32 genome-wide association studies showed that, while all traits are...

Topics

Genetic Predisposition to Disease
Genome
Genome-Wide Association Study
Humans
Likelihood Functions
Linkage Disequilibrium
Mental Disorders
Models, Genetic
Multifactorial Inheritance
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Risk Factors

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PMID: 30104760
DOI: 10.1038/s41588-018-0193-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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