Article
Embracing polygenicity: a review of methods and tools for psychiatric genetics research.
Psychological medicine - 1 May 2018
Maier R M, Visscher P M, Robinson M R, Wray N R
Abstract excerpt
The availability of genome-wide genetic data on hundreds of thousands of people has led to an equally rapid growth in methodologies available to analyse these data. While the motivation for undertaking genome-wide association studies (GWAS) is identification of genetic markers associated with complex traits, once generated these data can be used for many other analyses. GWAS have demonstrated that complex traits...
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Mental Disorders
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Risk Factors