Article

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy

2023-03-12

Abstract excerpt

<h4>Summary</h4> Chemical genetic screens are a powerful tool for exploring how cancer cells’ response to drugs is shaped by their mutations, yet they lack a molecular view of the contribution of individual genes to the response to exposure. Here, we present sci-Plex- G ene-by- E nvironment (sci-Plex- G x E ), a platform for combined single-cell genetic and chemical screening at scale. We highlight the advant...

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Literature Corpus work: 2d1ae0d0-2914-58b0-9c2f-45efa9d5ff12
DOI: 10.1101/2023.03.10.531983

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