Article

A single-cell based precision medicine approach using glioblastoma patient-specific models

2021-01-15

Abstract excerpt

Glioblastoma (GBM) is a heterogeneous tumor made up of cell states that evolve over time. Here, we modeled tumor evolutionary trajectories during standard-of-care treatment using multimodal single-cell analysis of a primary tumor sample, corresponding mouse xenografts subjected to standard of care therapy, and recurrent tumor at autopsy. We mined the multimodal data with single cell SYstems Genetics Network AnaLys...

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Literature Corpus work: e9729c5b-a9b9-5dd1-bf1a-490d1d1f16d4
DOI: 10.1101/2021.01.13.426485

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