Article

A single-cell atlas linking intratumoral states to therapeutic vulnerabilities across cancers

2026-02-19

Abstract excerpt

Intratumoral heterogeneity (ITH) is a major determinant of therapeutic failure, yet its impact on drug response across cancers remains incompletely understood. Here, we present the Therapeutic Cancer Cell Atlas (TCCA), a pan-cancer single-cell resource integrating ~1.8 million transcriptomes from 537 patients and 183 cancer cell lines spanning 34 tumor types. By combining single-cell transcriptomics with copy-numb...

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Literature Corpus work: fbc04f59-cc1a-592d-b76c-f4d48ddb8be9
DOI: 10.64898/2026.02.18.706316

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