Article

A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase

2024-04-09

Abstract excerpt

Over-activation of the epidermal growth factor receptor (EGFR) is a hallmark of glioblastoma. However, EGFR-targeted therapies have led to minimal clinical response. While delivery of EGFR inhibitors (EGFRis) to the brain constitutes a major challenge, how additional drug-specific features alter efficacy remains poorly understood. We introduce SCHEMATIC, which integrates multiplex single-cell chemical transcriptom...

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Literature Corpus work: 567a2ca2-e5e1-5ccb-8c64-0e8a7a974885
DOI: 10.1101/2024.04.08.587960

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