Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies.

Communications biology - 4 Jan 2021

Sinkala Musalula, Nkhoma Panji, Mulder Nicola, Martin Darren Patrick

Abstract excerpt

The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular processes that fuel the malignant transformation of normal cells. The molecular aberrations which lead to cancer involve mutations in, and transcription variations of, various MAPK pathway genes. Here, we examine the genome sequences of 40,848 patient-derived tumours representing 101 distinct human cancers to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Benzamides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Benzimidazoles

Share to Cell Survival

Share to Drug Evaluation, Preclinical

Share to MAP Kinase Signaling System

Share to MCF-7 Cells

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 33398072
DOI: 10.1038/s42003-020-01552-6
PMCID: PMC7782843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies.PMID 33398072Read ↗

Integrated Molecular Characterisation of the MAPK Pathways in Human CancersSemantic proximity Read ↗

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and SensitivitySemantic proximity Read ↗

Genome-wide profiling identifies the genetic dependencies of cell death following EGFR inhibitionSemantic proximity Read ↗

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapySemantic proximity Read ↗

Targeting the ERK/MAPK Pathway in Cancer: Oncogenic Mechanisms, Therapeutic Resistance, and Emerging Gene-Based StrategiesSemantic proximity Read ↗

Deciphering the genetic landscape of cancer--from genes to pathways.Semantic proximity Read ↗

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants.Semantic proximity Read ↗

Precision drugging of the MAPK pathway in head and neck cancerSemantic proximity Read ↗

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines.Semantic proximity Read ↗

Targeting MAPK in Cancer 2.0Semantic proximity Read ↗

A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization.Semantic proximity Read ↗

Molecular pathways: mitogen-activated protein kinase pathway mutations and drug resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.