Article

Integrated Molecular Characterisation of the MAPK Pathways in Human Cancers

2020-03-16

Abstract excerpt

The mitogen-activated protein kinase (MAPK) pathways are a crucial regulator of the cellular processes that fuel the malignant transformation of normal cells. The genetic underpinnings of molecular aberrations which lead to cancer involve mutations in and, transcription variations of, various MAPK pathway genes. Here, we use datasets of 40,848 patient-derived tumours representing 101 distinct human cancers to iden...

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Literature Corpus work: 7bd6f9df-a16a-5382-8890-381b068e366a
DOI: 10.1101/2020.03.14.989350

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