Article

Functional genomics identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomas

2026-02-03

Abstract excerpt

High-grade gliomas (HGGs) are aggressive tumors with poor outcomes and limited treatment options. Here, we combined genomic and transcriptomic tumor profiling with drug testing in a patient-derived 3-dimensional culture model to identify individualized treatments and predictive biomarkers. Activity of single agents targeting frequently dysregulated glioma pathways was relatively poor ex vivo and generally reflect...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ad3653d-18bb-5d60-bd69-6600f87443df
DOI: 10.64898/2026.02.01.701806

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional genomics identifies therapeutic options, biomarkers, and resistance mechanisms for high-grade gliomasDOI 10.64898/2026.02.01.701806Read

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read

Multi-omics and pharmacological characterization of patient-derived glioma cell linesSemantic proximity Read

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.Semantic proximity Read

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomasSemantic proximity Read

Patient-Derived Orthotopic Xenografts and Cell Lines from Pediatric High-Grade Glioma Recapitulate the Heterogeneity of Histopathology, Molecular Signatures, and Drug ResponseSemantic proximity Read

BRD4/H3K27Ac Epigenetic Reprogramming Orchestrates Chemotherapy-induced Polyploid Giant Cancer Cells and Glioma ProgressionSemantic proximity Read

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Semantic proximity Read

Functional profiling of murine glioma models highlights targetable immune evasion phenotypesSemantic proximity Read

Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPGSemantic proximity Read

IGF2 associated PI3K signaling shapes temozolomide sensitivity in glioblastomaSemantic proximity Read

Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in gliomaSemantic proximity Read

Hidden-driver inference reveals synergistic brain-penetrant therapies for medulloblastomaSemantic proximity Read