Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution.

doi:10.1016/j.cell.2026.08.035

Article

Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution.

Cell - 17 Sept 2026

Zhang Jesse, Ubas Airol A, Svensson Valentine, Thomas Nicole, Subramanyam Vishvak, Carpenter Christopher, Winters Aidan, de Borja Richard, Teyssier Noam, Thakar Neha, Khan Umair, Akella Pooja V, Green Harper J, Thompson John D, Tran Vuong, Pangallo Joseph, Papalexi Efthymia, Sapre Ajay, Nguyen Hoai, Sanderson Oliver, Nigos Maria, Kaplan Olivia, Schroeder Sarah, Hariadi Bryan, Marrujo Simone, Curca Crina, Salvino Alec, Gallareta Olivares Guillermo, Koehler Ryan, Rosenberg Alexander, Roco Charles, Ricci-Tam Chiara, Jones Matthew G, Dobin Alexander, Plosky Brian S, Lyons Danielle E, Merico Daniele, Alidoust Nima, Goodarzi Hani, Yu Johnny

Abstract excerpt

We present Tahoe-100M, a giga-scale single-cell perturbation atlas comprising 100 million transcriptomes from 50 diverse cancer cell lines treated with 1,100 drug-dose conditions. This parallel profiling of thousands of perturbations at single-cell resolution with minimal batch effects is enabled by the Mosaic platform, which multiplexes genetically distinct cell models into balanced "cell villages." Beyond...

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Humans
Single-Cell Analysis

Tahoe-100M: Mapping drug-induced molecular phenotypes at single-cell resolution.

Abstract excerpt

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