Article
A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma.
Cell reports - 14 Jul 2020
Johansson Patrik, Krona Cecilia, Kundu Soumi, Doroszko Milena, Baskaran Sathishkumar, Schmidt Linnéa, Vinel Claire, Almstedt Elin, Elgendy Ramy, Elfineh Ludmila, Gallant Caroline, Lundsten Sara, Ferrer Gago Fernando J, Hakkarainen Aleksi, Sipilä Petra, Häggblad Maria, Martens Ulf, Lundgren Bo, Frigault Melanie M, Lane David P, Swartling Fredrik J, Uhrbom Lene, Nestor Marika, Marino Silvia, Nelander Sven
Abstract excerpt
Glioblastoma (GBM) is a malignant brain tumor with few therapeutic options. The disease presents with a complex spectrum of genomic aberrations, but the pharmacological consequences of these aberrations are partly unknown. Here, we report an integrated pharmacogenomic analysis of 100 patient-derived GBM cell cultures from the human glioma cell culture (HGCC) cohort. Exploring 1,544 drugs, we find that GBM has two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.