Article

Driver-associated transcriptional rewiring reveals conditional genetic vulnerabilities in cancer

2024-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Mutations within cancer driver genes induce widespread transcriptional changes that reflect altered cellular states and can reveal associated genetic vulnerabilities. However, it remains challenging to determine which genes are dysregulated as a consequence of cancer alterations, and of these, which represent therapeutic opportunities. Here, we present Dyscovr, an integrative computational frame...

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Literature Corpus work: 37d31a8c-62e5-59af-ba6a-53867f0926fc
DOI: 10.1101/2024.11.20.624509

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