Article

Pax6 and KDM5C co-occupy a subset of developmentally critical genes including Notch signaling regulators in neural progenitors

2019-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Pax6 is a key transcription factor in neural development. While generally viewed as a transcriptional activator, mechanisms underlying Pax6 function as a repressor is less well understood. Here we show that Pax6 acts as a direct repressor of transcription associated with a decrease in H3K4me3 levels. Genome wide analysis of the co-occupancy of the H3K4 demethylase KDM5C and Pax6 with H3K4me3-neg...

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Literature Corpus work: 2d101d15-755e-5490-946c-3787d296addc
DOI: 10.1101/579219

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