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PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

12 Jul 2024

Abstract excerpt

SNCAIP duplication may promote Group 4 medulloblastoma via induction of PRDM6, a poorly characterized member of the PRDF1 and RIZ1 homology domain-containing (PRDM) family of transcription factors. Here, we investigated the function of PRDM6 in human hindbrain neuroepithelial stem cells and tested PRDM6 as a driver of Group 4 medulloblastoma. We report that human PRDM6 localizes predominantly to the nucleus,...

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PMID: 38992221
DOI: 10.1038/s41598-024-66811-6

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