Article

KDM6A knockout in human iPSCs alters the genome-wide histone methylation profile at active and poised enhancers, activating expression of ectoderm gene expression pathways

2021-03-09

Abstract excerpt

KDM6A is a histone demethylase, known to remove methyl moieties at the lysine residues of histone 3-labeled (H3K27me3) poised enhancers and bivalent promoters, which regulates gene expression during the differentiation of embryonic stem cells and tissue-specific development. However, while tissue- and disease-specific analyses have been performed, little is known about the location and consequences on gene express...

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Literature Corpus work: 81530a2e-2624-57b0-8c81-975a97aa530c
DOI: 10.1101/2021.03.09.434633

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