Article

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

2023-08-31

Abstract excerpt

<h4>ABSTRACT</h4> SNCAIP duplication may promote Group 4 medulloblastoma via induction of PRDM6, a poorly characterized member of the PRDF1 and RIZ1 homology domain-containing (PRDM) family of transcription factors. Here, we investigated the function of PRDM6 in human hindbrain neuroepithelial stem cells and tested PRDM6 as a driver of Group 4 medulloblastoma. We report that human PRDM6 localizes predominantly...

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Literature Corpus work: 782d8749-52a0-5ee0-8688-b93643d7b611
DOI: 10.1101/2023.08.29.555389

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