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RLS-associated MEIS transcription factors control distinct processes in human neural stem cells

22 Nov 2024

Abstract excerpt

MEIS1 and MEIS2 encode highly conserved homeodomain transcription factors crucial for developmental processes in a wide range of tissues, including the brain. They can execute redundant functions when co-expressed in the same cell types, but their roles during early stages of neural differentiation have not been systematically compared. By separate knockout and overexpression of MEIS1 and MEIS2 in human neural...

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PMID: 39578497
DOI: 10.1038/s41598-024-80266-9

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