Article

Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylation

2023-09-27

Abstract excerpt

<h4>Background</h4> Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development, disease, and cancer, how the molecular agents collectively shape the H3K36me landscape is unclear. <h4>Results</h4> We use a mouse mesenchymal stem cell model to perturb the H3K36me deposition machinery and infer t...

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Literature Corpus work: 347ae172-3a2c-50c0-a6c3-2e7fab642433
DOI: 10.1101/2023.09.27.559313

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Systematic perturbations of SETD2, NSD1, NSD2, NSD3 and ASH1L reveals their distinct contributions to H3K36 methylationDOI 10.1101/2023.09.27.559313Read

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