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Article

BRD4 represses developmental and neuronal genes through interaction with PRC1.6

2026-01-31

Abstract excerpt

BRD4 is best known as a transcriptional co-activator, yet heterozygous loss-of-function variants cause craniofacial and neurodevelopmental abnormalities through unclear mechanisms. Using human embryonic stem cells and neural organoids as an in vitro model of human embryonic brain development, we show that BRD4 represses polycomb-regulated developmental and neuronal genes. BRD4 co-occupies bivalent promoters with P...

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Literature Corpus work
ed114af3-97a3-5855-8b07-fc32bc87ce9a
DOI
10.64898/2026.01.31.702994
Open publication

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BRD4 represses developmental and neuronal genes through interaction with PRC1.6DOI 10.64898/2026.01.31.702994
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