Article

Comparative benchmarking of CRISPRi and CasRx in standardized pluripotent stem cell platforms reveals context-dependent knockdown performance

2026-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Advances in transcriptome profiling have revealed transcriptomic differences across different cellular states. However, functional interpretation requires precise perturbation tools and experimental frameworks. This study benchmarked two widely used modalities: CRISPR interference (CRISPRi) and Cas13d/CasRx. A standardized workflow was established to generate human pluripotent stem cells (PSCs)...

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Literature Corpus work: 3aa1f9d8-9fdd-599e-8ea8-d0ee702dd54b
DOI: 10.64898/2026.05.13.724469

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