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Pooled Genome-Scale CRISPR Screens in Single Cells.

Annual review of genetics - 27 Nov 2023

Schraivogel Daniel, Steinmetz Lars M, Parts Leopold

Abstract excerpt

Assigning functions to genes and learning how to control their expression are part of the foundation of cell biology and therapeutic development. An efficient and unbiased method to accomplish this is genetic screening, which historically required laborious clone generation and phenotyping and is still limited by scale today. The rapid technological progress on modulating gene function with CRISPR-Cas and...

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PMID: 37562410
DOI: 10.1146/annurev-genet-072920-013842

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